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PET/CT has significant advantages over traditional methods in detecting and staging lesions in patients with natural killer/T-cell lymphoma, a study published on December 18th found. Helion.
In a retrospective analysis, a team in Taiyuan, China found that F-18 FDG-PET/CT was superior in analyzing imaging findings in NK/T cell lymphoma, suggesting that this scan could improve treatment plans for patients. suggested.
“F-18 FDG-PET/CT scans are critical in identifying tumor lesions, determining staging, and devising treatment strategies for individuals diagnosed with NK/T-cell lymphoma,” said lead author No. Yamanishi. wrote Huixia Geng, MD, of the Tri-Hospital. medical university.
NK/T cell lymphomas originate from mature T cells and NK cells. The authors explained that although the disease has a low incidence, it progresses rapidly and patient survival is poor.
Previous studies have shown that F-18 FDG-PET/CT is important for determining staging, response assessment, and prognostic assessment of diffuse large B-cell lymphoma, Hodgkin lymphoma, and follicular lymphoma. However, it has not yet been established in NK patients. /T-cell lymphoma, they added.
To achieve this objective, the research group analyzed the PET/CT image features of 38 patients with a primary diagnosis of NK/T-cell lymphoma and compared their approach to traditional methods, namely physical examination, venography, and Comparisons were made with CT, MRI, and biopsy from the primary site. , bone marrow examination, etc.
According to the analysis, patients had a total of 219 lesions (including 81 nodular lesions and 138 extranodal lesions) with positive malignancy tests. PET/CT significantly outperformed conventional methods in detecting malignant lesions, detecting 79 extranodal lesions (98.8%) compared to 45 (56.3%).
Furthermore, the clinical staging of 15.7% (6 of 38) of patients was reclassified to varying degrees after PET/CT findings, and the PET/CT results were This helped me change my treatment plan. the group wrote.
Specifically, there were 2 cases in which radiation therapy alone was changed to radiation therapy combined with chemotherapy, and 2 cases in which chemotherapy combined with radiation therapy was changed to chemotherapy alone due to stage-up. PET/CT scans changed the target area for radiation therapy in three patients, the researchers added.
“Our results suggest that PET/CT has significant advantages over it. [conventional methods] “Useful for lesion detection and staging of extranodal NK/T-cell lymphoma,” the group wrote.
Ultimately, the authors point out that the advantage of PET/CT is that it can combine both structural imaging and functional metabolic information. According to the authors, this non-invasive hybrid approach allows clinicians to analyze the morphology, location, and invasion of lesions in a single examination, compared to traditional sequential methods.
“Our findings in NK/T-cell lymphoma highlight the importance of PET/CT in lesion detection and early staging,” the research group concluded.
You can read the full article here.
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